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DEA warns fentanyl mixtures may limit naloxone effectiveness

The U.S. Drug Enforcement Administration says fentanyl is increasingly mixed with other synthetic substances that can reduce the effectiveness of naloxone, the standard overdose reversal drug.

Published May 12, 2026, 5:05 PM EDT | WFMZZ

The U.S. Drug Enforcement Administration warned that fentanyl is increasingly being combined with a range of synthetic substances. The agency says those mixtures can limit the effectiveness of naloxone, potentially complicating overdose reversal efforts.