MLB 2026 Opening Day schedule: starts 1:15 p.m., ends with Guardians‑Mariners at 10:10 p.m.
The 2026 MLB season opens Thursday with a full Opening Day slate beginning at 1:15 p.m. ET and wrapping up with a 10:10 p.m. ET Guardians‑Mariners matchup.
The 2026 Major League Baseball season launches a full-scale Opening Day on Thursday with a packed schedule set to begin at 1:15 p.m. ET and run through the conclusion of a 10:10 p.m. ET matchup between the Cleveland Guardians and Seattle Mariners.